What are quinazoline derivatives?
The quinazoline derivative CEP-32496 is a novel, orally active BRAF inhibitor identified to be highly effective against the proliferation of multiple BRAF(V600E)-dependent cancer cell lines and BRAF(V600E)-dependent xenograft mouse models of human colorectal cancer [82, 83].
Which drug consist Quinazolinone ring?
Quinazoline and quinazolinone-based drugs. Several quinazolinone-based drugs including idelalisib and fenquizone have been shown to exhibit a broad spectrum of antimicrobial, antitumor, antifungal, and cytotoxic activities [20]. Lapatinib has been displayed to be effective in combination therapy for breast cancer [21].
What is quinazoline used for?
One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities.
Who discovered quinazoline?
The synthesis of quinazoline was first reported in 1895 by August Bischler and Lang through the decarboxylation of the 2-carboxy derivative (quinazoline-2-carboxylic acid).
What is pteridine ring explain?
[ tĕr′ĭ-dēn′ ] Any of a group of organic compounds having two fused six-member rings each containing two nitrogen atoms and four carbon atoms. One of the rings is a pyrimidine, the other a pyrazine. Pteridines include folic acid and the pigments of butterfly wings.
What is thiazole ring?
Thiazole is a heterocyclic organic compound that has a five-membered molecular ring structure with molecular formula C3H3NS.
Which drug contains Quinazoline alkaloids?
The pharmacologically important tryptanthrine, a quinazoline alkaloid, is known for its antimycotic activity and is used against skin infections. This alkaloid is obtained from isatin (260) and o-azidobenzoyl chloride (261), as shown in Scheme 96.
What is indole group?
Indole is an aromatic heterocyclic organic compound with formula C8H7N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria.
Which is pteridine derivative?
Triamterene, a pteridine derivative, is a diuretic that acts by inhibiting sodium reabsorption in the late distal tubule and collecting ducts.
What is pyrrole ring?
Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH. It is a colorless volatile liquid that darkens readily upon exposure to air.
What is pyran ring?
In chemistry, pyran, or oxine, is a six-membered heterocyclic, non-aromatic ring, consisting of five carbon atoms and one oxygen atom and containing two double bonds. The molecular formula is C5H6O. There are two isomers of pyran that differ by the location of the double bonds.
Is atropine a Tropane alkaloid?
Tropane alkaloids (TPA) occur mostly in the Solanaceae and include the anticholinergic drugs atropine, hyoscyamine, and scopolamine, as well as the narcotic, topical anesthetic cocaine.
Quinazoline derivatives, which belong to the N-containing heterocyclic compounds, have caused universal concerns due to their widely and distinct biopharmaceutical activities.
Why are quinazolines important in Medicinal Chemistry?
One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities.
What is the structure of quinazolinone?
Quinazolinone is a heterocyclic chemical compound, a quinazoline with a carbonyl group in the C 4 N 2 ring. Two isomers are possible: 2-quinazolinone and 4-quinazolinone, with the 4-isomer being the more common. These compounds are of interest in medicinal chemistry.
What are the derivatives of quinazolinones conjugated with lysine?
A series of urea/thiourea/acetamide/sulphonamide derivatives of quinazolinones conjugated with lysine have been synthesized by Suresha and coworkers. All compounds have been evaluated against variety of pathogens for their antibacterial activity and structure-activity relationship has been developed.