How effective is topotecan?
Topotecan was reported to be effective as second-line treatment for SCLC 7. In a randomised phase III study, topotecan (1.5 mg·m-2 i.v., days 1–5, every 21 days) was at least as effective as the three-drug regimen of cyclophosphamide 1,000 mg·m-2, doxorubicin 45 mg·m-2 and vincristine 2 mg (CAV).
How effective is Hycamtin?
At 1 year, the survival rate was 33% after treatment with oral topotecan and 29% after treatment with IV topotecan; the 2-year survival rates were 12% for oral topotecan and 7% for IV topotecan.
What is the mode of action of topotecan?
Topotecan has the same mechanism of action as irinotecan and is believed to exert its cytotoxic effects during the S-phase of DNA synthesis. Topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks.
What is Topotecan FDA approved for?
The US Food and Drug Administration (FDA) has approved oral topotecan (Hycamtin) capsules for the treatment of relapsed small-cell lung cancer (SCLC).
How long can you take topotecan?
Topotecan is usually given every day for 3 to 5 days.
What is the cost of topotecan?
The cost for topotecan intravenous powder for injection 4 mg is around $152 for a supply of 1 powder for injection, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.
How long does it take for topotecan to work?
This 3-day or 5-day treatment is given again every 21 days until your body responds to the medicine. Each treatment usually takes at least 30 minutes. Topotecan often causes nausea and vomiting.
How does topotecan cause cell death?
While the principal mechanism of tumor cell killing by topotecan is due to its interactions with topoisomerase I and formation of DNA double-strand breaks, recent studies suggest that mechanisms involving generation of reactive free radicals and induction of oxidative stress may play a significant role in topotecan- …
When was topotecan approved by FDA for SCLC?
Hycamtin (topotecan) – 3 indications the treatment of Stage IV-B, recurrent, or persistent cervical cancer; approved July 2006. the treatment of small cell lung cancer; approved October 2007.
What is another name for topotecan?
Topotecan is a chemotherapy drug and is also known by its brand names, Hycamtin and Potactasol.
What class of drug is topotecan?
Topotecan is in a class of medications called topoisomerase I inhibitors. It works by killing cancer cells.
What is Topotecan Injection?
Topotecan injection is used to treat patients with metastatic cancer (a cancer that has already spread) of the ovaries after other treatments have failed. This medicine is also used to treat a certain type of lung cancer called small cell lung cancer.