How serious is synovial sarcoma?
We know that anywhere from 36% to 76% of people with synovial sarcoma will be alive five years after their first diagnosis. Chances of survival are better if the tumor is completely removed and does not return or spread.
What is the best treatment for synovial sarcoma?
Surgery is the mainstay of treatment for synovial sarcoma. The goal is to remove the cancer and a margin of healthy tissue around it. This can sometimes mean the removal of an entire muscle or muscle group, or even amputation.
Is synovial sarcoma malignant?
Like other malignant soft tissue tumors, synovial sarcoma is an uncommon form of cancer. It affects about 1,000 people each year. It’s most often seen in people under age 30 and more commonly seen in males.
Who gets synovial sarcoma?
Very few people get this disease. It accounts for less than 1% of all cancers. Doctors usually find it in teens and young adults (ages 15 to 35). If you or someone you love has it, there are treatments and clinical trials that you can choose with your doctor.
Can synovial sarcoma spread to brain?
There are scattered case reports of synovial sarcoma with metastasis to the brain, and other sarcomas are known to rarely cause hemorrhagic brain lesions.
Can a synovial sarcoma spread to lungs?
Yes, synovial sarcoma often does spread to other parts of the body. The lungs are the most common, and usually the first, site of metastasis for synovial sarcoma. Metastasis to the brain, bone, lymph nodes and local organs are all possibilities.
What causes synovial sarcoma?
Cause. The exact underlying cause of synovial sarcoma is poorly understood. However, studies show that a certain genetic change is identified in more than 90% of cases. More specifically, a translocation between chromosome X and chromosome 18 appears to play a role in the development of synovial sarcoma.
What is synovial chondromatosis (Reichel syndrome)?
Synovial chondromatosis (osteochondromatosis or synovial chondrometaplasia) also known as Reichel syndrome, is a disorder characterized by loose cartilaginous bodies which may, or may not be calcified or ossified. It is classified under two main types:
Which X-rays are used in the workup of synovial chondromatosis?
In severe cases of synovial chondromatosis, the loose bodies may grow large enough to occupy the entire joint space or penetrate into adjacent tissues. In these x-rays of an elbow joint (left) and ankle joint (right), the loose bodies are clearly visible. (Left) Reproduced from Johnson TR, Steinbach LS (eds.): Essentials of Musculoskeletal Imaging.
What is the treatment for synovial chondromatosis?
During this time, your doctor will closely monitor the affected joint to check for the progression of osteoarthritis. Treatment for synovial chondromatosis typically involves surgery to remove the loose bodies of cartilage. In some cases, the synovium is also partially or fully removed (synovectomy) during surgery.
How does synovial fluid cause osteoarthritis?
The synovial fluid nourishes the loose bodies and they may grow, calcify (harden), or ossify (turn into bone). When this occurs, they can roll around freely inside the joint space. As they roll around, the loose bodies can damage the smooth articular cartilage that covers the joint, causing osteoarthritis.