What are the classification of NSAIDs?
NSAIDs are typically divided into groups based on their chemical structure and selectivity: acetylated salicylates (aspirin), non-acetylated salicylates (diflunisal, salsalate), propionic acids (naproxen, ibuprofen, acetic acids (diclofenac, indomethacin), enolic acids (meloxicam, piroxicam) anthranilic acids ( …
What is the mechanism of action of mefenamic acid?
Mefenamic acid has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of mefenamic acid, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Mefenamic acid is a potent inhibitor of prostaglandin synthesis in vitro.
What is chemical name of mefenamic acid?
Mefenamic acid is a white to greyish-white, odorless, microcrystalline powder with a melting point of 230°-231°C and water solubility of 0.004% at pH 7.1. The chemical name is N-2,3-xylylanthranilic acid. The molecular weight is 241.29.
What is the indication of mefenamic acid?
Mefenamic acid is used for the short-term treatment of mild to moderate pain from various conditions. It is also used to decrease pain and blood loss from menstrual periods. Mefenamic acid is known as a nonsteroidal anti-inflammatory drug (NSAID).
What class of NSAID is diclofenac?
Diclofenac is a medication used in the management and treatment of inflammatory conditions and pain. It is in the class of non-steroidal anti-inflammatory drugs (NSAID).
What functional group is mefenamic acid?
|CAS Number (of the unlabelled compound)||61-68-7|
|Shipping Hazards||NON-HAZARDOUS FOR TRANSPORT|
|Functional Groups||Amines & Amine Salts,Carboxylic Acids & Salts|
What is COX 1 and cox2?
COX-1 is thought to be responsible for the production of prostaglandins associated with normal physiologic function and is found in such tissues as the stomach, kidney, and platelets. COX-2 was thought to be induced as the result of inflammation and responsible for producing prostaglandins such as prostaglandin E2.
What is the component element of mefenamic acid?
Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor.
What is the contraindication of mefenamic acid?
Mefenamic acid is contraindicated in patients with salicylate hypersensitivity or NSAID hypersensitivity who have experienced asthma, urticaria, or other allergic reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactoid reactions to mefenamic acid have been reported in such patients.
Is mefenamic acid an antibiotic?
Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that is used short-term (7 days or less) to treat mild to moderate pain in adults and children who are at least 14 years old. Mefenamic acid is also used to treat menstrual pain.
What is COX and LOX?
Cyclooxygenases (COX-1/2) and lipoxygenases (LOX) are well-recognized as pro-inflammatory enzymes as well as vital enzymes in the metabolic pathway of arachidonic acid1.