What causes mucosal Melanosis?

What causes mucosal Melanosis?

Various stimuli that can result in an increased production of melanin at the level of mucosa include trauma, hormones, radiation and medications. Three such cases are reported in which stimulus for genesis of melanosis was mechanical trauma in form of smoking.

What is the most common pigmentation of oral mucous membranes?

The closer the pigmentation to the surface, the darker the color (black). The amalgam tattoo is the most common localized, pigmented lesion of the oral mucosa, affecting 3.3% of the US adult population.

What causes oral pigmentation?

Mucosal pigmentation can occur due to deposition of exogenous foreign materials such as dental amalgam, tattoo pigment, or graphite. By far the most common of these is unintended implantation of amalgam, known as amalgam tattoo, which affects 3.3% of the US adult population [47].

What is mucosal Melanosis?

Abstract. Background: Melanosis (lentiginosis, labial melanotic macula) is a benign pigmented lesion of mucosa characterized by pigmentation of basal keratinocytes with melanocytic normal or slightly increased in number.

How is oral Melanosis treated?

In conclusion, cryotherapy has been described as the most suitable treatment options for physiological oral melanosis. It is simple yet effective method for treating oral pigmentation with minimal trauma to the patient. Alternatively, lasers can be used to treat physiological oral melanosis.

What color is oral melanoma?

Oral melanomas are often silent with minimal symptoms until the advanced stage. The lesions can appear as pigmented dark brown to blue-black lesions or apigmented mucosa-colored or white lesions on physical examination.

What color is oral mucosa?

Oral mucosa is generally pink in colour. Highly keratinized, firm, stippled and pale masticatory mucosa cover the hard palate, dorsal surface of tongue, and gingiva. Thin, less keratinized and more pinkish non-masticatory mucosa cover the remaining intra-oral structures.

What disorders causes pigmentation in the oral cavity and skin?


  • Racial pigmentation.
  • Black hairy tongue.
  • Amalgam tattoo.
  • Peutz–Jeghers syndrome.
  • Addison’s disease.
  • Kaposi’s sarcoma.
  • Smoker’s melanosis.
  • Oral melanoacanthoma.

What color is Melanosis?

Symptoms. Typically seen on an endoscopy, melanosis coli is usually a dark brown or black color that can vary in darkness and intensity.

What does oral melanoma look like?

Oral melanomas are often silent with minimal symptoms until the advanced stage. The lesions can appear as pigmented dark brown to blue-black lesions or apigmented mucosa-colored or white lesions on physical examination. Erythema may be present if inflammation is present.

What drugs cause oral pigmentation?

Pigmentation can be produced by various drugs like, hormones, oral contraceptives, chemotherapeutic agents like cyclophosphamide, busulfan, bleomycin and fluorouracil, transquilizers, antimalarials like clofazamine, chloroquine, amodiaquine, anti-microbial agents like minocycline, anti-retroviral agents like zidovudine …

What does melanoma inside the mouth look like?

What causes black and brown pigmentation of the oral mucosa?

Black and brown pigmentation of the oral mucosa can occur due to a multitude of non-neoplastic causes. Endogenous or exogenous pigments may be responsible for oral discoloration which can range from innocuous to life-threatening in nature.

What is pigmentation in the mucosa?

Conclusion Pigmentation is defined as the process of deposition of pigments in tissues. Various diseases can lead to varied colorations in the mucosa. It can arise from intrinsic and extrinsic factors and can be physiological or pathological. The dentist should be aware of the various lesions to aid in the proper treatment plan.

What does brown discoloration of the mouth look like?

Brown to Black Discoloration. In the oral cavity, the most commonly involved sites are the inner lining of the cheeks followed by the gums, tongue and lips. The color of the oral mucosa varies from bluish-black to pale brown or deep chocolate-colored pigments spread over from the cheek mucosa to the corner of the mouth.

What is the pathophysiology of oral mucosa color change?

Color changes in the oral mucosa can be attributed to the deposition of either endogenous or exogenous pigments as a result of various mucosal diseases. The various pigmentations can be in the form of blue/purple vascular lesions, brown melanotic lesions, brown heme-associated lesions, gray/black pigmentations.