What is oxaliplatin and capecitabine?
Oxaliplatin and capecitabine is a chemotherapy treatment usually used to treat bowel cancer. This combination of drugs may also be used to treat other types of cancer. It is sometimes called XELOX or CAPOX.
What type of chemotherapy is oxaliplatin based?
Drug Type: Oxaliplatin is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.
What is bevacizumab made of?
Bevacizumab is formulated with 51 mM sodium phosphate pH 6.2, 60 mg/ml α,α-trehalose dihydrate and 0.04% polysorbate 20. The drug product is a clear to slightly opalescent, colourless to pale brown sterile liquid solution that has to be diluted in 0.9 % sodium chloride solution prior to administration.
What is the difference between capecitabine and fluorouracil?
Abstract. Fluorouracil (5-FU) remains the most widely used agent for colorectal cancer. Capecitabine is a rationally designed 5-FU pro-drug developed to mimic the continuous infusion of 5-FU while avoiding complications and inconvenience of intravenous administration.
What is oxaliplatin made of?
About: Oxaliplatin (Eloxatin®) Oxaliplatin is a type of platinum chemotherapy, which are made up of heavy metal compounds that inhibit synthesis of RNA, DNA, and protein in cells. All of these are vital for cells to divide and grow.
What is the mechanism of action of oxaliplatin?
Oxaliplatin disrupts DNA replication and transcription by forming intrastrand DNA adducts, but the downstream molecular events underlying the cytotoxic effects of this chemotherapeutic agent have not been well characterised.
What type of drug is oxaliplatin?
Oxaliplatin is a type of chemotherapy drug. It is also called Eloxatin. It’s a treatment for bowel cancer and some other types of cancer. You usually have oxaliplatin in combination with other chemotherapy drugs.
What is oxaliplatin made from?
This medication is used to treat advanced cancer of the colon and rectum. Oxaliplatin is a chemotherapy drug that contains platinum.
What type of drug is bevacizumab?
Bevacizumab injection products are in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumors. This may slow the growth and spread of tumors.
What is another name for bevacizumab?
Bevacizumab is a cancer treatment drug and is also known by its brand name, Avastin. It is a treatment for many different types of cancers.
Is 5-FU effective without oxaliplatin?
Cox regression analyses found no significant difference in survival with the addition of oxaliplatin to 5-FU regimens. Conclusion: Our findings suggested no survival benefit with the addition of oxaliplatin to 5-FU modalities in treating CRC in practice.
Is fluorouracil the same as 5-FU?
Fluorouracil is also known as FU or 5FU and is one of the most commonly used drugs to treat cancer. It is most often used in combination with other cancer drugs to treat many types of cancer including: breast cancer. head and neck cancers.
What is the pharmacologic activity of capecitabine?
Capecitabine is a prodrug and has little pharmacologic activity until it is converted to fluorouracil, an antimetabolite.
What type of ester is capecitabine?
Capecitabine is a carbamate ester that is cytidine in which the hydrogen at position 5 is replaced by fluorine and in which the amino group attached to position 4 is converted into its N- (penyloxy)carbonyl derivative. Capecitabine is a antineoplastic agent used in the treatment of cancers.
Is capecitabine toxic to the liver?
Capecitabine is associated with a low rate of transient serum aminotransferase elevations during therapy but has been only rarely implicated in cases of clinically apparent acute liver injury. Capecitabine has known transformation products that include 2′,3′-di-O-acetyl-5′-deoxy-5-fluorocytidine.
What is the peak plasma concentration of capecitabine and fluorouracil?
According to the manufacturer, peak plasma concentrations of capecitabine occur in about 1.5 hours, and peak plasma concentrations of fluorouracil, its active drug, occur slightly later at 2 hours. American Society of Health System Pharmacists. AHFS Drug Information 2008. Bethesda, Maryland 2008, p. 963