What are 3 factors that affect drug absorption?
These include:
- physicochemical properties (e.g. solubility)
- drug formulation (e.g. tablets, capsules, solutions)
- the route of administration (e.g. oral, buccal, sublingual, rectal, parenteral, topical, or inhaled)
- the rate of gastric emptying.
Which factor affects the absorption of drugs from Git?
Drug absorption from the gastrointestinal tract
| Drug factors: | |
|---|---|
| Concentration | A large drug dose will be absorbed more rapidly because of the high concentration gradient |
| Intestinal motility | Intestinal motility can increase or decrease absorption (eg. slow gut transit can ensure complete absorption of a drug bezoar) |
What affects drug absorption the most?
Because most absorption occurs in the small intestine, gastric emptying is often the rate-limiting step. Food, especially fatty food, slows gastric emptying (and rate of drug absorption), explaining why taking some drugs on an empty stomach speeds absorption.
What are the factors affecting adsorption?
What is Adsorption?
- Factors affecting the extent of adsorption. The extent to which adsorption will happen on a solid surface depends on the following factors:
- Nature of adsorbent. The adsorption of the gas depends on the nature of the adsorbent.
- Surface area.
- Nature of the gas.
- Exothermic nature.
- Pressure.
What affects absorbance?
The two main factors that affect absorbance are concentration of the substance and path length. Relation between concentration and absorbance: Absorbance is directly proportional to the concentration of the substance. The higher the concentration, the higher its absorbance.
What are the different factors affecting drug absorption and elimination?
1. Drug dose, route of administration, rate and extent of absorption, distribution rate (particularly to site of action) and rate of elimination. 2. The minimum effective concentration and concentration-effect relationship.
What increases drug absorption?
Physiologically, a drug’s absorption is enhanced if there is a large surface area available for absorption (e.g. villi/microvilli of intestinal tract) and if there is a large blood supply for the drug to move down its concentration gradient.
What are the factors affecting drug action?
This chapter, therefore, deals with the following factors which modify drug action: (1) route of administration, (2) rate and degree of absorption, (3) rate of elimination, (4) effect of other drugs, (5) tolerance, (6) idiosyncrasy and allergy, (7) disease.
Which of the following factors that affect the selection of absorbent?
Factors Affecting Adsorption
- (i) Nature and Surface Area of the Adsorbent.
- (ii) The Nature of the Adsorbed Gas.
- (iii) Temperature.
- (iv) Pressure of the gas.
Does pH affect adsorption?
The pH of the contact solution is an important parameter controlling the adsorption process. The adsorption capacity decreases as the acidity of the contact solution increases.
Does pH affect absorbance?
The increasing pH values resulted in the greater wavelength of absorbance peak, suggesting the increased aromaticity and conjugated degree, and the novel fluorescence peak was found in λ(ex/em) = 250/450.
Does temperature affect absorbance?
The absorption of aqueous glucose decreases with the increasing of temperature, also the absorbance decreases.