What is positive for PAX8?
PAX8-positive, calretinin-negative staining appears to be highly specific and sensitive for detecting metastatic ovarian serous carcinoma in cytological preparations and may prove useful for distinguishing these cells from mesothelial cells in fluid cytology (32).
What is negative for PAX8?
PAX8 as an Immunohistochemical Marker for Mesothelioma. PAX8 is considered a negative marker for mesothelioma. This means mesothelioma cancer cells usually do not test positive for PAX8. PAX8 is a common marker for kidney cancer, thyroid cancer and cancers of the female reproductive system.
What does PAX8 stand for?
Paired box gene 8, also known as PAX8, is a protein which in humans is encoded by the PAX8 gene.
What does CK7 positive mean?
What does positive for CK7 mean? Positive for CK7 means that immunohistochemistry was performed and CK7 protein was seen inside the cells of interest in the tissue sample. Reactive is another term that pathologists use to describe cells that are producing CK7.
What is metastatic high grade serous carcinoma?
High-grade serous carcinoma is the most common type of ovarian cancer, accounting for approximately 75% of epithelial ovarian cancers. Because it is the most common type of ovarian cancer, it is often the default type that’s referenced in discussions of ovarian cancer, unless another type is specified.
What does gata3 positive mean?
A recent study found GATA-3 to be associated with favorable breast cancer pathologic features, including negative lymph node and positive estrogen receptor (ER) status. GATA-3 levels were also found to be an independent prognostic marker, with low expression predicting for breast cancer recurrence.
What is vimentin positive?
In conclusion, vimentin-positive gastric cancer was associated with the highly invasive phenotype of advanced gastric cancer, especially with scirrhous type of gastric carcinoma. Vimentin may play an important role in the metastasis of gastric carcinoma.
What is PAX8 biology?
PAX8 Gene – Paired Box 8 Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes.
What WT1 positive?
WT1-positive tumors included tumor of the stomach, prostate, and biliary and urinary systems, and malignant melanomas. A majority of the positive cases showed diffuse or granular staining in the cytoplasm, whereas ovarian tumors and desmoplastic small round cell tumors frequently showed nuclear staining.
What is PAX8 and why is it important?
PAX8 is a nephric-lineage transcription factor and is a crucial transcription factor for organogenesis of the thyroid gland, kidney, and Müllerian system. PAX8 is shown to be expressed in a high percentage of kidney and ovarian carcinomas. Limited information is known about the specificity of PAX8 i …
Do polyclonal PAX8 antibodies cross react with PAX5 antibodies?
Polyclonal PAX8 antibodies are known to cross react with PAX5 (e.g. B cell lymphocytes, B cell lymphoma) and PAX6 (e.g. pancreatic islet cells, neuroendocrine tumors of select sites)
Is there a role for the PAX8 gene in carcinoma?
1 Department of Pathology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA. PAX8 is a paired-box gene important in embryogenesis of the thyroid, Müllerian, and renal/upper urinary tracts, and expression of PAX8 has been previously described in carcinomas from each of these sites.
What is the PAX8 immunohistochemistry test?
PAX8 immunohistochemistry was performed on 1357 tumors (486 tumors in whole-tissue sections and 871 tumors in tissue microarrays, predominantly epithelial) from multiple organs. Only nuclear staining was scored as positive, and tumors were evaluated for the extent and intensity of staining.