What is the function of glutathione S transferase?
Glutathione S-transferases (GSTs) are ubiquitous enzymes that are encoded by a large gene family, and they contribute to the detoxification of endogenous or xenobiotic compounds and oxidative stress metabolism in plants.
How can I increase my glutathione S transferase?
Eating sulfur rich foods may increase glutathione levels in the body. Sulfur occurs in several amino acids, two of which — methionine and cysteine — are precursors for glutathione and therefore contribute to its synthesis .
Is glutathione S transferase an antioxidant?
Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis. Antioxid Redox Signal.
Where is glutathione S transferase found?
cytosol
The glutathione transferases (GSTs; also known as glutathione S-transferases) are major phase II detoxification enzymes found mainly in the cytosol. In addition to their role in catalysing the conjugation of electrophilic substrates to glutathione (GSH), these enzymes also carry out a range of other functions.
What are the examples of transferases?
Classification
| EC number | Examples |
|---|---|
| EC 2.3 | acyltransferase |
| EC 2.4 | glycosyltransferase, hexosyltransferase, and pentosyltransferase |
| EC 2.5 | riboflavin synthase and chlorophyll synthase |
| EC 2.6 | transaminase, and oximinotransferase |
Is glutathione S transferase a protein?
The glutathione S-transferases (GSTs) are an abundant family of dimeric proteins that have the capacity to conjugate glutathione (GSH) with a variety of compounds containing electrophilic centers.
What are natural sources of glutathione?
The human body produces glutathione, but there are also dietary sources. Spinach, avocados, asparagus and okra are some of the richest dietary sources ( 13 ). However, dietary glutathione is poorly absorbed by the human body.
What is GST pulldown assay?
GST pull-down assays involve affinity purifications of one or several unknown proteins from a biological sample using a GST-tagged bait protein. The basic principle is that the GST-tagged bait protein binds to its partners, and the resulting complex is captured on beads with immobilized glutathione.
What is the role of transferase and give example?
Transferases are enzymes that catalyze the transfer of a functional group from one molecule to another. An example is acyl transferases that catalyze the transfer of acyl groups. An example is the peptidyl transferase.
What is meant by transferase?
Definition of transferase : an enzyme that promotes transfer of a group from one molecule to another.
Is there a role for glutathione transferases in resistance to herbicides?
A role for glutathione transferases functioning as glutathione peroxidases in resistance to multiple herbicides in black-grass. Plant J. 1999;18:285–292.
Are glutathione S-transferases involved in the detoxification of metolachlor?
Characterization of glutathione S-transferases in the detoxification of metolachlor in two maize cultivars of differing herbicide tolerance. 1. Pestic Biochem Physiol. 2017 Nov;143:265-271. doi: 10.1016/j.pestbp.2016.12.003.
What is the role of glutathione S-transferase/glutathione peroxidase in transgenic tobacco seedling growth?
Overexpression of glutathione S-transferase/glutathione peroxidase enhances the growth of transgenic tobacco seedlings during stress. Nat Biotechnol. 1997;15:988–991. One of the first clear accounts of the importance of GSTs in oxidative stress tolerance in planta. [PubMed] [Google Scholar] Cummins I, Cole DJ, Edwards R.
What is the role of glutathione in plant cell stress signaling?
Loyall L, Uchida K, Braun S, Furuya M, Frohnmeyer H. Glutathione and a UV light-induced glutathione S-transferase are involved in signaling to chalcone synthase in cell cultures. Plant Cell. 2000;12:1939–1950. The first indication that tau GSTs are involved in plant cell stress signaling. [PMC free article][PubMed] [Google Scholar]
