What does hepatocyte growth factor do?
As a growth factor, HGF promotes the growth and survival of cancer cells, increases tumor aggressiveness, stimulates metastasis and is associated with resistance to therapy (95, 96). Recently, established colon cancer cell lines and primary colon tumors have been shown to produce large amounts of HGF (97).
What is the other name of hepatocyte growth factor?
Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.
Where is hepatocyte growth factor produced?
Abstract. Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met.
Is hepatocyte growth factor a cytokine?
Hepatocyte growth factor (HGF), otherwise known as scatter factor (SF), is a recently identified cytokine which exerts a wide spectrum of biological functions on a variety of cell types.
Is hepatocyte growth factor safe?
The long diameter of 8 of 11 ischemic ulcers in 4 patients was reduced >25%. Intramuscular injection of naked HGF plasmid is safe, feasible, and can achieve successful improvement of ischemic limbs.
Is FGF an oncogene?
We now term this oncogene the FGF-5 gene, since it specifies the fifth documented protein related to fibroblast growth factors (FGFs.
What causes high TGF b1?
What does it mean if your TGF-b1 result is too high? – TGF B-1 is often chronically over-expressed in disease states, including cancer, fibrosis and inflammation. – TGF B-1 is moderately to extremely high in Chronic Inflammatory Response Syndrome due to water-damaged buildings (CIRS).
What does high TGF B mean?
How can I lower my TGF beta?
The main strategies for inhibition of TGF-β signaling pathway is to include compounds that interfere with the binding of TGF-β to its receptors, drugs that block intracellular signaling, and antisense oligonucleotides.