What is domain in RNA?
The RNA-recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain) is the most abundant RNA-binding domain in higher vertebrates (this motif is present in about 0.5%-1% of human genes)3 and is the most extensively studied RNA-binding domain, both in terms of structure and …
What is the full form of hnRNA?
HnRNA stands for heterogeneous nuclear RNA. As its name suggests, hnRNA is a term that encompasses various types and sizes of RNAs found in the eukaryotic cell nucleus.
What is meant by heterogeneous RNA?
Heterogeneous nuclear RNA (hnRNA) refers to the bulk of transcribed RNA that has not been processed.
What is RBM in biology?
Abstract. RBM5 is a known modulator of apoptosis, an RNA binding protein, and a putative tumor suppressor. Originally identified as LUCA-15, and subsequently as H37, it was designated “RBM” (for RNA Binding Motif) due to the presence of two RRM (RNA Recognition Motif) domains within the protein coding sequence.
What is DNA dependent RNA polymerase?
The DNA-dependent RNA polymerase (DdRP or RNAP) is an essential enzyme of transcription of replicating systems of prokaryotic and eukaryotic organisms as well as cytoplasmic DNA viruses.
Why is RNA called hnRNA?
The hnRNA is the collective term for the unprocessed mRNA (pre-mRNA) molecules in the nucleus. It is largely comprised of the pre-mRNA molecules that require extensive processing to become mature mRNA molecules. The hnRNA that is associated with proteins form the heterogenous nuclear ribonucleoprotein (hnRNP).
What is the difference between hnRNA and mRNA?
The key difference between hnRNA and mRNA is that hnRNA is the unprocessed premature mRNA transcript that contains introns while mRNA is the processed RNA that does not contain introns. There are different types of RNA, and hnRNA and mRNA are two types of them.
What is the structure of hnRNP U?
The hnRNP U is the largest hnRNP family member and is mainly present in the nucleus where it is able to bind pre-mRNA and ssDNA. It contains an N-terminus rich in acidic residues and a glycine-rich C-terminus, and within the middle of the protein a glutamine stretch together with an NLS sequence.
How do hnRNPs interact with RNA enhancer elements?
This enhancer complex also contains hnRNP F, and hnRNPs F and H are shown to interact in vitro. Thus, interactions between multiple hnRNPs and RNA enhancer elements may be critical for splicing enhancer function. 31.
What are hnRNPs and why do they matter?
These proteins function in a staggering array of cellular activities, ranging from transcription and pre-mRNA processing in the nucleus to cytoplasmic mRNA translation and turnover. Recent studies suggest that several fundamental characteristics of hnRNPs account for their involvement in multiple regulatory pathways.
What is the role of hnRNP U in caspase-9 splicing?
Vu NT, Park MA, Shultz JC, et al. hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L. J Biol Chem. 2013;288:8575–8584. doi: 10.1074/jbc.M112.443333. [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]