What is Leukine used for?
It is used to help your body make more white blood cells. White blood cells are important to help you fight off infections. Sargramostim is given to people whose ability to make white blood cells is reduced (for instance, due to chemotherapy or exposure to large amounts of radiation).
What type of drug is Leukine?
Drug type: Leukine is a biologic response modifier. Leukine is classified as a colony stimulating factor.
What are Leukine injections?
What Is Leukine? Leukine (sargramostim) is a protein that stimulates the production of white blood cells used to increase white blood cells and decrease the risk of infection in conditions such as cancer, bone marrow transplant, and pre-chemotherapy blood cell collection.
What is the generic name for Leukine?
Leukine (sargramostim) is a granulocyte-macrophage colony-stimulating factor (GM-CSF). It works like the naturally occurring G-CSF protein in your body to stimulate bone marrow to make neutrophils, a type of white blood cell that helps your body fight infections.
Does leukine need to be refrigerated?
Store LEUKINE solution and reconstituted lyophilized LEUKINE solutions under refrigeration at 2°C-8°C (36°F-46°F); DO NOT FREEZE.
How is Leukine administered?
The recommended dose is 250 mcg/m2/day administered intravenously over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. Do not administer LEUKINE until the post marrow infusion ANC is less than 500 cells/mm3.
Is Leukine FDA approved?
On March 29, 2018, the FDA approved use of Leukine (sargramostim) to increase survival in adult and pediatric patients acutely exposed to myelosuppressive doses of radiation (Hematopoietic Syndrome of Acute Radiation Syndrome, or H-ARS). Myelosuppression occurs when radiation damages the bone marrow.
How do you administer Leukine?
How do you administer leukine?
The recommended dose is 250 mcg/m²/day administered intravenously over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. Do not administer LEUKINE until the post marrow infusion ANC is less than 500 cells/mm³.
Who makes leukine?
Partner Therapeutics, Inc.
In 2018, Partner Therapeutics, Inc. (PTx) acquired the global rights to develop, manufacture, and commercialize Leukine ® (sargramostim) from Sanofi.
How do you mix leukine?
Reconstitute LEUKINE for Injection aseptically with 1 mL of diluent. Do not mix the contents of vials reconstituted with different diluents together. Reconstitute with either Sterile Water for Injection, USP (without preservative) or Bacteriostatic Water for Injection, USP (0.9% benzyl alcohol).
How do you give Leukine injections?
What is Leukine and how does it work?
What is Leukine? Leukine ( sargramostim) is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.
What is Leukine for acute myeloid leukemia?
Acute Myeloid Leukemia Following Induction Chemotherapy. LEUKINE is indicated to shorten time to neutrophil recovery and to reduce the incidence of severe, life-threatening, or fatal infections following induction chemotherapy in adult patients 55 years and older with acute myeloid leukemia (AML).
What are the possible side effects of Leukine?
Leukine can cause infusion-related reactions. Infusion-related reactions may be characterized by respiratory distress, hypoxia, flushing, hypotension, syncope, and/or tachycardia following the first administration of Leukine in a particular cycle.
What is the efficacy of Leukine in the treatment of bacteremia?
Compared to placebo, administration of Leukine significantly improved the following: time to neutrophil engraftment, duration of hospitalization, number of patients with bacteremia, and overall incidence of infection (see Table 8 ).